Extensive-expression animal studies haven't been executed to assess the carcinogenic likely of codeine or of promethazine, nor are there other animal or human information about carcinogenicity, mutagenicity, or impairment of fertility with these agents.
This medication may possibly make you a lot more delicate on the Solar. Limit your time and effort while in the Sunshine. Stay clear of tanning booths and sunlamps. Use sunscreen and don protecting garments when outdoor. Notify your health care provider instantly if you have sunburned or have skin blisters/redness.
Cold, clammy skin dry mouth fainting no hypertension or pulse no muscle mass tone or motion pinpoint pupils (black Element of the eye) stopping of the guts unconsciousness Some Negative effects may happen that sometimes do not require medical attention.
The diagnostic evaluation of people with this particular syndrome is difficult. In arriving at a prognosis, it is important to recognize cases wherever the clinical presentation features equally critical clinical sickness (e.
When utilized for an extended time, this medication might not get the job done also and should call for diverse dosing. Speak with your medical professional if this medication stops Functioning nicely.
Absorption Codeine is absorbed from the gastrointestinal tract with maximum plasma concentration developing sixty minutes publish administration. The presence of a high-Extra fat, superior-calorie meal didn't significantly influence the PK of codeine.
The following critical adverse reactions are described, or explained in higher depth, in other sections:
The Promethazine codeine syrup phosphate salt of codeine occurs as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and a bit soluble in Liquor. The molecular weight is 406.37. Its molecular formulation is C18H21NO3•H3PO4 • ½ H2O, and it's got the subsequent chemical structure.
These side effects might go away through cure as Your entire body adjusts to your drugs. Also, your wellness treatment Qualified might be able to show you about approaches to stop or minimize Many of these Unwanted effects. Examine along with your overall health care Experienced if any of the following Uncomfortable side effects carry on or are bothersome or When you've got any questions on them:
Animal reproduction research have not been executed While using the drug blend-promethazine and codeine. It isn't recognised whether or not this drug mix could cause fetal harm when administered to a pregnant lady or can have an impact on replica capability.
Consider this medication by mouth with or devoid of food stuff as directed by your health practitioner, generally just about every four to six hours as required. This medication is usually taken with food if belly upset happens. Consume a good amount of fluids once you use this medication Until usually directed by your medical doctor.
Everyday living-threatening respiratory melancholy and Demise have occurred in children who received codeine. Many of the noted instances occurred adhering to tonsillectomy and/or adenoidectomy, and lots of of the children had proof of becoming an extremely-fast metabolizer of codeine as a consequence of a CYP2D6 polymorphism [see Warnings and Safety measures (5.
This isn't an entire list of doable Unintended effects. For those who recognize other Negative effects not stated over, contact your health practitioner or pharmacist.
Concomitant administration of promethazine goods with other respiratory depressants has an association with respiratory melancholy, and occasionally Loss of life, in pediatric sufferers.